Abstract | BACKGROUND: In diverse organisms, adaptation to low oxygen ( hypoxia) is mediated through complex gene expression changes that can, in part, be mimicked by exposure to metals such as cobalt. Although much is known about the transcriptional response to hypoxia and cobalt, little is known about the all-important cell metabolism effects that trigger these responses. METHODS AND FINDINGS: CONCLUSIONS: These studies underscore the notion that cobalt targets a specific class of iron proteins and provide the first evidence for hypoxia effects on amino acid regulation. This research illustrates the power of metabolite profiling for uncovering new adaptations to environmental stress.
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Authors | Julie E Gleason, David J Corrigan, James E Cox, Amit R Reddi, Lauren A McGinnis, Valeria C Culotta |
Journal | PloS one
(PLoS One)
Vol. 6
Issue 9
Pg. e24741
( 2011)
ISSN: 1932-6203 [Electronic] United States |
PMID | 21931840
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Fatty Acids
- Sterols
- Cobalt
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Topics |
- Cell Hypoxia
(drug effects, physiology)
- Chromatography, Gas
- Cobalt
(pharmacology)
- Fatty Acids
(metabolism)
- Gas Chromatography-Mass Spectrometry
- Immunoblotting
- Saccharomyces cerevisiae
(drug effects, metabolism)
- Sterols
(metabolism)
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