Abstract | OBJECTIVES: This study aimed to determine whether the treatment of pancreatic carcinoma can be defined on the basis of the expression of genes involved in gemcitabine metabolism and whether combination treatment is more effective than conventional treatment. METHODS: RESULTS: CONCLUSIONS: Combination treatment tailored to cells with highly expressed ribonucleotide reductase was more effective than treatment with gemcitabine alone. Moreover, phenotype and gemcitabine metabolism may independently confer chemoresistance.
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Authors | Naotake Funamizu, Yuko Kamata, Takeyuki Misawa, Tadashi Uwagawa, Curtis Ray Lacy, Katsuhiko Yanaga, Yoshinobu Manome |
Journal | Pancreas
(Pancreas)
Vol. 41
Issue 1
Pg. 107-13
(Jan 2012)
ISSN: 1536-4828 [Electronic] United States |
PMID | 21926937
(Publication Type: Journal Article)
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Chemical References |
- ABCB9 protein, human
- ABCG2 protein, human
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
- Antigens, CD
- Antineoplastic Agents
- CDH1 protein, human
- Cadherins
- Homeodomain Proteins
- Multidrug Resistance-Associated Proteins
- Neoplasm Proteins
- Snail Family Transcription Factors
- Transcription Factors
- Vimentin
- ZEB1 protein, human
- Zinc Finger E-box-Binding Homeobox 1
- Deoxycytidine
- Ribonucleotide Reductases
- Hydroxyurea
- multidrug resistance-associated protein 1
- Gemcitabine
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Topics |
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
(genetics, metabolism)
- Antigens, CD
- Antineoplastic Agents
(pharmacology)
- Blotting, Western
- Cadherins
(genetics, metabolism)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Deoxycytidine
(analogs & derivatives, pharmacology)
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
(drug effects, genetics)
- Gene Expression Regulation, Neoplastic
(drug effects)
- Homeodomain Proteins
(genetics, metabolism)
- Humans
- Hydroxyurea
(pharmacology)
- Multidrug Resistance-Associated Proteins
(genetics, metabolism)
- Neoplasm Proteins
(genetics, metabolism)
- Pancreatic Neoplasms
(enzymology, genetics, pathology)
- RNA Interference
- Reverse Transcriptase Polymerase Chain Reaction
- Ribonucleotide Reductases
(antagonists & inhibitors, genetics, metabolism)
- Snail Family Transcription Factors
- Transcription Factors
(genetics, metabolism)
- Vimentin
(genetics, metabolism)
- Zinc Finger E-box-Binding Homeobox 1
- Gemcitabine
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