Abstract |
The causes of clinical signs associated with syringomyelia in the Cavalier King Charles Spaniel (CKCS) are incompletely understood. In this study we compared expression of two pain-related neuropeptides: substance P (SP) and calcitonin gene related peptide (CGRP), in the spinal cord dorsal horn of normal dogs with that in CKCS with and without clinical signs of syringomyelia. There was a decrease in expression of both peptides in CKCS with 'symptomatic' syringomyelia that was also associated with significant asymmetry in SP-I and similar, though non-significant, asymmetry in CGRP-I compared with other groups. The asymmetric distribution of these pain-related peptides may be a consequence of syrinx-associated damage to grey matter but may also play a role in generation of pain.
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Authors | Hilary Zhaoxu Hu, Clare Rusbridge, Fernando Constantino-Casas, Nick Jeffery |
Journal | Research in veterinary science
(Res Vet Sci)
Vol. 93
Issue 1
Pg. 318-20
(Aug 2012)
ISSN: 1532-2661 [Electronic] England |
PMID | 21925690
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Substance P
- Calcitonin Gene-Related Peptide
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Topics |
- Animals
- Calcitonin Gene-Related Peptide
(analysis, metabolism)
- Dog Diseases
(metabolism, pathology)
- Dogs
- Spinal Cord
(chemistry, metabolism, pathology)
- Substance P
(analysis, metabolism)
- Syringomyelia
(metabolism, pathology, veterinary)
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