Abstract |
A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire. A total of 983 cases reportedly had acute encephalopathy during the past 3 years, 2007-2010. Among the pathogens of the preceding infection, influenza virus was the most common, followed by human herpesvirus-6 (HHV-6) and rotavirus. Among syndromes of acute encephalopathy, acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was the most frequent, followed by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS), acute necrotizing encephalopathy (ANE) and hemorrhagic shock and encephalopathy syndrome (HSES). Influenza virus was strongly associated with ANE and MERS, HHV-6 with AESD, and rotavirus with MERS. Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathy. Neurologic sequelae were common in AESD and ANE, but were absent in MERS.
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Authors | Ai Hoshino, Makiko Saitoh, Akira Oka, Akihisa Okumura, Masaya Kubota, Yoshiaki Saito, Jun-Ichi Takanashi, Shinichi Hirose, Takanori Yamagata, Hideo Yamanouchi, Masashi Mizuguchi |
Journal | Brain & development
(Brain Dev)
Vol. 34
Issue 5
Pg. 337-43
(May 2012)
ISSN: 1872-7131 [Electronic] Netherlands |
PMID | 21924570
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. |
Topics |
- Adolescent
- Child
- Child, Preschool
- Encephalitis
(epidemiology, etiology)
- Female
- Health Surveys
- Humans
- Incidence
- Infant
- Influenza, Human
(complications)
- Japan
(epidemiology)
- Male
- Roseolovirus Infections
(complications)
- Rotavirus Infections
(complications)
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