[Effect of cepharanthin on radiotherapy induced leukopenia].

Abstract

Cepharanthin, a kind of alkaloid, has been reported to show a protective effect for leukopenia induced by radiation therapy. In this study, one of three kinds of drugs, Cepharanthin, S-Adchnon (adrenochrome derivative) and Hythiol (L-cysteine), was randomly administered to 94 patients with cancer of the head and neck, the uterine cervix and the lung, during the course of radiotherapy. When Cepharanthin was given, 81.3% of the patients were protected from leukopenia, compared with 51.6% in S-Adchnon and 32.3% in Hythiol. It is suggested that prophylactic use of Cepharanthin may be useful for cancer radiotherapy.

• Authors: T Ohta, K Morita
• Journal: Rinsho hoshasen. Clinical radiography (Rinsho Hoshasen) Vol. 35 Issue 4 Pg. 471-4 (Apr 1990) ISSN: 0009-9252 [Print] Japan
• PMID: 2192184 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Alkaloids
• Benzylisoquinolines
• Radiation-Protective Agents
• S-Adchnon
• Adrenochrome
• cepharanthine
• Cysteine

Topics

• Adrenochrome (analogs & derivatives, therapeutic use)
• Alkaloids (therapeutic use)
• Benzylisoquinolines
• Cysteine (therapeutic use)
• Female
• Humans
• Leukopenia (drug therapy, etiology)
• Neoplasms (radiotherapy)
• Radiation-Protective Agents (therapeutic use)
• Radiotherapy (adverse effects)
• Randomized Controlled Trials as Topic