Abstract | BACKGROUND: Published trials evaluating pressure garment and/or silicone therapy as a treatment for hypertrophic burn scarring are of poor quality and highly susceptible to bias. The authors' aim was to compare the efficacy of pressure garment therapy alone and in combination with silicone gel sheet or spray therapy for the prevention of hypertrophic scarring. METHODS: The authors conducted an open, single-center, randomized controlled study with intraindividual comparison of study preparations and control to standard treatment. Forty-three consecutive patients with two comparable areas of split-thickness graft burn wounds were recruited into the study, and 38 patients were followed up for 18 months. All patients received compression garments and were randomized to one of two treatment groups: (1) self-drying silicone spray and compression versus compression alone and (2) silicone sheeting and compression versus compression alone. Clinical assessment, measurement of scar redness, height, and photographic documentation of each treated area were performed at different visits over an 18-month follow-up period. Significance was tested using repeated-measures analyses and Wilcoxon paired-sample signed rank tests. RESULTS: CONCLUSION: CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
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Authors | Lars Steinstraesser, Ewa Flak, Bernd Witte, Andrej Ring, Daniel Tilkorn, Jörg Hauser, Stefan Langer, Hans-Ulrich Steinau, Sammy Al-Benna |
Journal | Plastic and reconstructive surgery
(Plast Reconstr Surg)
Vol. 128
Issue 4
Pg. 306e-313e
(Oct 2011)
ISSN: 1529-4242 [Electronic] United States |
PMID | 21921743
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Burn Units
- Burns
(diagnosis, therapy)
- Cicatrix, Hypertrophic
(prevention & control)
- Compression Bandages
- Debridement
(methods)
- Female
- Humans
- Injury Severity Score
- Male
- Middle Aged
- Occlusive Dressings
- Prospective Studies
- Risk Assessment
- Silicone Gels
(therapeutic use)
- Single-Blind Method
- Statistics, Nonparametric
- Treatment Outcome
- Wound Healing
(physiology)
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