Abstract | BACKGROUND AND AIM: METHODS: Korean men (n = 593, 30-79 yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. RESULTS:
Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ- linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/ linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R(2) = 0.378). Interestingly, baPWV (1419 ± 1 cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (< 12.361%) and higher proportion of DGLA (≥ 1.412%) in serum phospholipid FAs. CONCLUSION: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.
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Authors | O Y Kim, H H Lim, M J Lee, J Y Kim, J H Lee |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 23
Issue 4
Pg. 366-74
(Apr 2013)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 21920716
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Biomarkers
- Fatty Acids
- Phospholipids
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Topics |
- Adiponectin
(blood)
- Analysis of Variance
- Ankle Brachial Index
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, complications, diagnosis, physiopathology)
- Chi-Square Distribution
- Cross-Sectional Studies
- Fatty Acids
(blood)
- Humans
- Insulin Resistance
- Linear Models
- Male
- Metabolic Syndrome
(blood, complications, diagnosis, physiopathology)
- Middle Aged
- Phospholipids
(blood)
- Predictive Value of Tests
- Pulse Wave Analysis
- Republic of Korea
- Vascular Stiffness
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