Abstract | OBJECTIVE: Our previous in vitro study demonstrated that glyceollins help normalize glucose homeostasis by potentiating β-cell function and survival in insulinoma cells as well as improving glucose utilization in adipocytes. Here, we investigated whether fermented soybeans containing glyceollins had an antidiabetic action in type 2 diabetic animals. METHODS: The diabetic mice, their diabetes induced by intraperitoneal injections of streptozotocin (20 mg/kg bw), were administered a high fat diet with no soybeans (control), 10% unfermented soybeans and 10% fermented soybeans containing glyceollins, respectively, (FSG) for 8 weeks. As positive controls, rosiglitazone (20 mg/kg/bw) was given to diabetic mice fed a no soybean diet and non-diabetic mice were also placed on the same diet. RESULTS: CONCLUSION:
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Authors | Sunmin Park, Da Sol Kim, Jeong Hwan Kim, Jong Sang Kim, Hyo Jung Kim |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 28
Issue 2
Pg. 204-11
(Feb 2012)
ISSN: 1873-1244 [Electronic] United States |
PMID | 21917419
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
- Peroxisome Proliferator-Activated Receptors
- Pterocarpans
- Thiazolidinediones
- Triglycerides
- Rosiglitazone
- glyceollin
- Glycogen
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Experimental
(diet therapy)
- Diet, High-Fat
- Fermentation
- Glucose Tolerance Test
- Glycogen
(metabolism)
- Homeostasis
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Insulin
(blood)
- Liver
(drug effects, enzymology, metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Peroxisome Proliferator-Activated Receptors
(agonists)
- Phosphorylation
- Pterocarpans
(pharmacology, therapeutic use)
- Rosiglitazone
- Soybeans
(chemistry)
- Thiazolidinediones
(pharmacology)
- Triglycerides
(metabolism)
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