Abstract |
Here we report a case with positive serum anti- aquaporin 4 (AQP4) antibody who presented with hypersomnolence, symmetrical hypothalamic lesions and a reduced CSF orexin ( hypocretin) level without optic nerve and spinal cord lesions on MRI. All of the symptoms, MRI finding and CSF orexin level improved simultaneously after steroid therapy. AQP4 is a member of the AQP superfamily which is strongly expressed in the hypothalamus where orexin ( hypocretin)-containing neurons are primarily concentrated. Although there have been only a few reports similar to our case, the present case suggests a close relationship between the positive serum anti-AQP4 antibody and symmetrical hypothalamic lesions with hypersomnolence and without optic /spinal lesion, which is improved by steroid treatment.
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Authors | Kentaro Deguchi, Syoichiro Kono, Shoko Deguchi, Nobutoshi Morimoto, Masami Ikeda, Tomoko Kurata, Yoshio Ikeda, Tohru Matsuura, Takashi Kanbayashi, Toshiyuki Takahashi, Koji Abe |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 312
Issue 1-2
Pg. 18-20
(Jan 15 2012)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 21917270
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- AQP4 protein, human
- Aquaporin 4
- Autoantibodies
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Topics |
- Adult
- Aquaporin 4
(immunology)
- Autoantibodies
(blood)
- Diagnosis, Differential
- Disorders of Excessive Somnolence
(diagnosis, immunology, pathology)
- Female
- Humans
- Hypothalamus
(immunology, pathology)
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