Aldactazine/captopril combination, safe and effective in mild to moderate systemic hypertension: report on a multicenter study of 967 patients.

Abstract	The safety and efficacy of a thiazide/potassium-sparing diuretic and an angiotensin-converting enzyme inhibitor used concomitantly was evaluated in a large, multicenter study. Aldactazine was administered alone for 2 months, after which time captopril was added in those whose blood pressure had not normalized (332 patients). At the end of the 6-month study, control of blood pressure was achieved in 88% of the patients with one or the other regimen. No clinically significant changes were recorded for a number of biologic parameters. Specifically, there was 1 case of hyperkalemia (6 mmol/liter), a very low incidence of hypotension (1.6%), and a low rate of adverse effects. Therefore, such a combination could provide important therapeutic benefits in hypertensive patients.
Authors	D C Schohn, R Spiesser, M Wehrlen, B Pelletier, M H Capron
Journal	The American journal of cardiology (Am J Cardiol) Vol. 65 Issue 23 Pg. 4K-6K (Jun 19 1990) ISSN: 0002-9149 [Print] United States
PMID	2191589 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
Chemical References	Benzothiadiazines Diuretics Drug Combinations Sodium Chloride Symporter Inhibitors Sulfonamides Spironolactone spironolactone, althiazide drug combination Captopril
Topics	Adolescent Adult Aged Benzothiadiazines Blood Pressure (drug effects) Captopril (administration & dosage, adverse effects, therapeutic use) Diuretics Drug Combinations (administration & dosage, adverse effects, therapeutic use) Drug Therapy, Combination Female Humans Hypertension (drug therapy, physiopathology) Male Middle Aged Multicenter Studies as Topic Sodium Chloride Symporter Inhibitors (administration & dosage, adverse effects, therapeutic use) Spironolactone (administration & dosage, adverse effects, therapeutic use) Sulfonamides (administration & dosage, adverse effects, therapeutic use)

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