Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions.

Abstract

The aim of this study was to assess the immunohistochemical expression of syndecan-1 (CD138) and Ki-67 in radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors (KOT). Thirty-five RC, 22 DC and 17 KOT were used in the study and immunohistochemical reactions using anti-syndecan-1 and anti-Ki-67 antibodies were performed by the streptavidin-biotin-peroxidase method. Fisher's exact test and Spearman's correlation coefficient were used for statistical analysis of data. Among the studied lesions, no differences in the syndecan-1 expression were observed, but the suprabasal expression of Ki-67 was significantly higher in KOT (p<0.0001), when compared with RC and DC. In RC, there was positive correlation between the expression (p=0.02) and intensity (p=0.0001) of syndecan-1 and between the intensity of syndecan-1 and Ki-67 expression (p=0.01). In the KOT, Ki-67 expression in the suprabasal layer correlated positively with the expression (p=0.01) and intensity (p=0.01) of syndecan-1. The expression of syndecan-1 does not seem to be a determinant factor of the distinct histopathological features and biological behavior of the studied lesions. Nevertheless, positive correlation between syndecan-1 and a cell proliferation marker was observed in RC and KOT.

• Authors: Michele Regina Nadalin, Eduardo Rodrigues Fregnani, Yara Teresinha Correa Silva-Sousa, Danyel Elias da Cruz Perez
• Journal: Brazilian dental journal (Braz Dent J) Vol. 22 Issue 3 Pg. 223-9 ( 2011) ISSN: 1806-4760 [Electronic] Brazil
• PMID: 21915520 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies
• Ki-67 Antigen
• SDC1 protein, human
• Syndecan-1

Topics

• Adolescent
• Adult
• Aged
• Antibodies
• Cell Proliferation
• Child
• Dentigerous Cyst (pathology)
• Epithelial Cells (pathology)
• Epithelium (pathology)
• Female
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Ki-67 Antigen (analysis)
• Male
• Mandibular Diseases (pathology)
• Mandibular Neoplasms (pathology)
• Maxillary Diseases (pathology)
• Middle Aged
• Odontogenic Cysts (pathology)
• Odontogenic Tumors (pathology)
• Radicular Cyst (pathology)
• Retrospective Studies
• Syndecan-1 (analysis)
• Young Adult