In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis.

Abstract

Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.

• Authors: Odalys Blanco, Yuliannis Lugones, Elaine Díaz, Lianet Monzote
• Journal: Revista do Instituto de Medicina Tropical de Sao Paulo (Rev Inst Med Trop Sao Paulo) 2011 Jul-Aug Vol. 53 Issue 4 Pg. 235-8 ISSN: 1678-9946 [Electronic] Brazil
• PMID: 21915470 (Publication Type: Journal Article)

Chemical References

• Antiprotozoal Agents
• Phospholipids
• Pulmonary Surfactant-Associated Proteins
• Pulmonary Surfactants
• surfacen

Topics

• Animals
• Antiprotozoal Agents (pharmacology)
• Leishmania mexicana (drug effects)
• Lethal Dose 50
• Macrophages, Peritoneal (parasitology)
• Mice
• Mice, Inbred BALB C
• Parasitic Sensitivity Tests
• Phospholipids (pharmacology)
• Pulmonary Surfactant-Associated Proteins (pharmacology)
• Pulmonary Surfactants (pharmacology)