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Dual protective role of HO-1 in transplanted liver grafts: a review of experimental and clinical studies.

Abstract
Liver transplantation is considered as the most effective treatment for end-stage liver disease. However, serious complications still exist, particularly in two aspects: ischemia and subsequent reperfusion of the liver, causing postoperative hepatic dysfunction and even failure; and acute and chronic graft rejections, affecting the allograft survival. Heme oxygenase (HO), a stress-response protein, is believed to exert a protective function on both the development of ischemia-reperfusion injury (IRI) and graft rejection. In this review of current researches on allograft protection, we focused on the HO-1. We conjecture that HO-1 may link these two main factors affecting the prognosis of liver transplantations. In this review, the following aspects were emphasized: the basic biological functions of HO-1, its roles in IRI and allograft rejection, as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.
AuthorsChun-Feng Wang, Zhen-Yu Wang, Ji-Yu Li
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 17 Issue 26 Pg. 3101-8 (Jul 14 2011) ISSN: 2219-2840 [Electronic] China
PMID21912452 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Heme Oxygenase-1
Topics
  • Graft Rejection (physiopathology, prevention & control)
  • Graft Survival (physiology)
  • Heme Oxygenase-1 (metabolism, therapeutic use)
  • Humans
  • Liver Diseases (surgery)
  • Liver Transplantation
  • Reperfusion Injury (physiopathology, prevention & control)
  • Treatment Outcome

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