Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: This was a case-control study conducted at a U.K. teaching hospital. Patients with type 1 diabetes aged >16 years (n = 1,000) were assessed for CD. HbA(1c), lipid profile, quality of life, retinopathy stage, nephropathy stage, and degree of neuropathy before and after 1 year on a GFD were assessed. RESULTS: The prevalence of CD was 33 per 1,000 subjects (3.3% [95% CI 2.3-4.6]). At diagnosis of CD, adult type 1 diabetic patients had worse glycemic control (8.2 vs. 7.5%, P = 0.05), lower total cholesterol (4.1 vs. 4.9, P = 0.014), lower HDL cholesterol (1.1 vs. 1.6, P = 0.017), and a higher prevalence of retinopathy (58.3 vs. 25%, P = 0.02), nephropathy (41.6 vs. 4.2%, P = 0.009), and peripheral neuropathy (41.6 vs. 16.6%, P = 0.11). There was no difference in quality of life (P > 0.1). After 1 year on a GFD, only the lipid profile improved overall, but in adherent individuals HbA(1c) and markers for nephropathy improved. CONCLUSIONS: Adults with undetected CD and type 1 diabetes have worse glycemic control and a higher prevalence of retinopathy and nephropathy. Treatment with a GFD for 1 year is safe in adults with type 1 diabetes and does not have a negative impact on the quality of life.
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Authors | John S Leeds, Andrew D Hopper, Marios Hadjivassiliou, Solomon Tesfaye, David S Sanders |
Journal | Diabetes care
(Diabetes Care)
Vol. 34
Issue 10
Pg. 2158-63
(Oct 2011)
ISSN: 1935-5548 [Electronic] United States |
PMID | 21911773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Blood Glucose
(metabolism)
- Case-Control Studies
- Celiac Disease
(blood, complications, diet therapy)
- Diabetes Mellitus, Type 1
(blood, complications, diet therapy)
- Diabetic Nephropathies
(blood, diet therapy, etiology)
- Diabetic Retinopathy
(blood, diet therapy, etiology)
- Diet, Gluten-Free
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Young Adult
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