HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - a randomized controlled trial.

AbstractPURPOSE OF THE RESEARCH:
The goal of this study was to assess the effect of oral cryotherapy on the development of oral mucositis related to infusion of 5-fluorouracil (5-FU) with leucovorin.
METHOD:
This study, a randomized controlled trial with random assignments to the experimental and control groups, was conducted with cancer patients. The study included 60 patients; 30 patients in the study group were instructed to hold ice cubes in their mouth shortly before, during, and shortly after infusion of 5-FU with leucovorin, the 30 patients in the control group received routine care. Oral mucositis in the patients was evaluated at 7, 14, and 21 days after chemotherapy. For analysis of data, chi-square, Fisher's tests were used; p < 0.05 was accepted as statistically significant.
RESULTS:
In the majority of patients receiving cryotherapy, oral mucositis was not observed (Grade 0) at 7 and 14 days. Similarly, incidence of Grades 1, 2, and 3 oral mucositis in the experimental group was quite a bit lower when compared to the control group (p < 0.05). On day 21, no statistically significant difference between the experimental and control groups was determined based on the development of oral mucositis (p > 0.05).
CONCLUSIONS:
We found that oral cryotherapy has a significant contribution to the protection of oral health by reducing mucositis score according to the WHO mucositis scale, especially on the 7th and 14th days. Nurses' awareness of how cryotherapy can affect patients and options for resolving problems will enable them to provide a higher standard of individualized care.
AuthorsNilgün Katranc─▒, Nimet Ovayolu, Ozlem Ovayolu, Alper Sevinc
JournalEuropean journal of oncology nursing : the official journal of European Oncology Nursing Society (Eur J Oncol Nurs) Vol. 16 Issue 4 Pg. 339-44 (Sep 2012) ISSN: 1532-2122 [Electronic] Scotland
PMID21911313 (Publication Type: Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2011 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Leucovorin
  • Fluorouracil
Topics
  • Antineoplastic Agents (adverse effects)
  • Cryotherapy
  • Female
  • Fluorouracil (adverse effects)
  • Humans
  • Leucovorin (adverse effects)
  • Male
  • Neoplasms (drug therapy)
  • Stomatitis (chemically induced, prevention & control)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: