Abstract | BACKGROUND: OBJECTIVE: The aim of this study was an in vitro evaluation of the efficacy of ropivacaine in reducing the degenerative effects usually observed during lidocaine treatment. METHODS:
Ropivacaine and lidocaine toxicity has been evaluated in murine fibroblasts 3T6 by measuring percentage of cell death, cell growth inhibition, and DNA degradation. The choice of this cellular line is motivated by the presence of a complete apoptotic system that can be assimilated to the endothelium precursor cells. RESULTS: We observed that lidocaine 0.25% decreases cell viability and causes DNA degradation in murine fibroblasts 3T6, whereas ropivacaine 0.5% does not cause any cellular or molecular degenerative effect. CONCLUSIONS:
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Authors | Nicola Pescosolido, Gianfranco Scarsella, Marco Tafani, Marcella Nebbioso |
Journal | Drugs in R&D
(Drugs R D)
Vol. 11
Issue 4
Pg. 303-7
(Dec 01 2011)
ISSN: 1179-6901 [Electronic] New Zealand |
PMID | 21910512
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amides
- Ropivacaine
- Lidocaine
|
Topics |
- Amides
(toxicity)
- Animals
- Cataract Extraction
(adverse effects)
- Cell Line
- Cell Survival
(drug effects, physiology)
- Fibroblasts
(drug effects, pathology)
- Lidocaine
(toxicity)
- Mice
- Pain, Postoperative
(chemically induced, prevention & control)
- Ropivacaine
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