[Effect of kangxin fulu recipe on electrophysiological functions of the sinoatrial node in rabbits with sick sinus syndrome].

Abstract

OBJECTIVE:

To study the effect of Kangxin Fulu Recipe (KFR) on electrophysiological functions of the sinoatrial node in rabbits with sick sinus syndrome (SSS).

METHODS:

Sixty big ears white rabbits were randomly divided into six groups, i.e., the normal group, the model group, the atropine group, the high dose KFR group, the middle dose KFR group, and the low dose KFR group, ten in each group. SSS model was established by injecting formaldehyde to the sinoatrial node except those in the normal group. Changes in AA interval, the sinoatrial conduction time (SACT), the sinus node recovery time (SNRT), and the corrected sinus node recovery time (CSNRT) were measured before and after modeling, seven days before and after gastrogavage.

RESULTS:

(1) The AA interval and SACT could be significantly shortened in the high dose KFR group, the middle-dose KFR group, and the atropine group (P<0.05, P<0.01). Better effects were obtained in the former two groups (P<0.05). (2) SNRT and CSNRT could be shortened in the high dose KFR group and the atropine group, with no statistical difference between the two groups (P>0.05).

CONCLUSION:

The electrophysiological mechanism of KFR might possibly be correlated with accelerating the recovery of sinus node autorhythmicity and conduction functions.

• Authors: Ru-xiu Liu, Ni-na Wang, Hui-bo Li
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 31 Issue 8 Pg. 1118-21 (Aug 2011) ISSN: 1003-5370 [Print] China
• PMID: 21910348 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drugs, Chinese Herbal
• Kangxin

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Heart Rate (drug effects)
• Rabbits
• Sick Sinus Syndrome (physiopathology)
• Sinoatrial Node (drug effects, physiopathology)