Abstract | BACKGROUND: METHODS: After ethical approval, 100 patients scheduled for laparoscopic cholecystectomy were ventilated using a tidal volume of 8 ml/kg, an inspiration:expiration ratio of 1:2.5, and a positive end-expiratory pressure (PEEP) of 5 cm H(2)O. At 15 min before CO(2) insufflation, the patients were randomly allocated into two groups of 50 patients each. For the normocapnia group, the respiratory rate (RR) was adjusted to maintain arterial CO(2) tension (PaCO(2)) at 35 to 45 mmHg. For the hypocapnia group, the RR was adjusted to maintain PaCO(2) at 30 to 35 mmHg. Anesthesia was maintained with sevoflurane 2% to 2.5% in 40% air oxygen and rocuronium. Hemodynamic variables, PaCO(2), end-tidal CO(2) tension (EtCO(2)), arterial-to-end-tidal CO(2) (Pa-ETCO(2)) gradient, and RR were recorded. RESULTS: Compared with the control group, the use of hypocapnia before and during pneumoperitoneum was associated with significantly lower arterial blood pressures, lower PaCO(2) and EtCO(2) values, a higher Pa-ETCO(2), a higher RR (p < 0.001), and less need for supplemental doses of fentanyl and labetalol. CONCLUSION:
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Authors | Mohamed R El-Tahan, Noha D Al Dossary, Hatem El Emam, Douaa G Diab, Abdulhadi Al'Saflan, Haitham Zien, Mona Al Ahmadey, Afrah Deria |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 26
Issue 2
Pg. 391-7
(Feb 2012)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 21909861
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Anesthesia, General
(methods)
- Blood Pressure
(physiology)
- Carbon Dioxide
(blood)
- Cholecystectomy, Laparoscopic
(methods)
- Double-Blind Method
- Female
- Heart Rate
(physiology)
- Hemodynamics
(physiology)
- Humans
- Insufflation
(methods)
- Male
- Partial Pressure
- Pneumoperitoneum, Artificial
(methods)
- Prospective Studies
- Respiration, Artificial
(methods)
- Respiratory Rate
(physiology)
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