Abstract | BACKGROUND:
Primary ciliary dyskinesia (PCD) is a clinically uniform entity, but cilia motility and structure can vary between patients, making the diagnostic difficult. The aim of this study was to evaluate the sensitivity and specificity in diagnosing PCD of a system of high-resolution digital high-speed video analysis with proprietary software that we developed for analysis of ciliary motility (Desinsoft-Bio 200). The secondary aim was to correlate nasal ciliary activity with clinical and structural abnormalities in PCD. MATERIAL AND METHODS: We analysed nasal mucociliary transport, cilia ultrastructure, nasal ciliary beat frequency and beat pattern studied by high-resolution digital high-speed video in 25 cases of PCD (11 Kartagener syndrome), 27 secondary ciliary dyskinesia and 34 healthy volunteers. RESULTS: CONCLUSION: Nasal mucociliary transport showed high sensitivity for PCD diagnosis with a low specificity. High-resolution digital high-speed video has a high sensitivity and specificity for diagnosing PCD. This system of video analysis is more useful than ultrastructural study and mucociliary transport for PCD screening. Dynein absence is correlated with cilia immotility and is more common in patients with Kartagener syndrome.
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Authors | Miguel Armengot, Mireya Bonet, Carmen Carda, María José Gómez, Javier Milara, Manuel Mata, Julio Cortijo |
Journal | Acta otorrinolaringologica espanola
(Acta Otorrinolaringol Esp)
2012 Jan-Feb
Vol. 63
Issue 1
Pg. 1-8
ISSN: 1988-3013 [Electronic] Spain |
PMID | 21907944
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Copyright | Copyright © 2011 Elsevier España, S.L. All rights reserved. |
Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Early Diagnosis
- Female
- Humans
- Infant
- Kartagener Syndrome
(diagnosis)
- Male
- Middle Aged
- Sensitivity and Specificity
- Young Adult
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