Abstract | PURPOSE: The purpose of the study was to validate diffusion-weighted imaging (DWI) in the assessment of hypervascular hepatocellular carcinoma (HCC) compared with superparamagnetic iron oxide ( SPIO)-enhanced magnetic resonance imaging (MRI) in the cirrhotic liver. MATERIAL AND METHODS: Forty-six consecutive patients with 106 hypervascular focal lesions in the cirrhotic liver who underwent DWI using three b factors and gadopentetate dimeglumine-enhanced dynamic MRI followed by SPIO-enhanced MRI were enrolled. Two independent radiologists evaluated two separated image sets ( SPIO set, dynamic MRI and SPIO-enhanced T2*-weighted images; DWI set, DWI and dynamic MRI) and assigned confidence levels for diagnosis of HCC using a five-point scale for each lesion. Area under the receiver operating characteristic curve (A(z)) was calculated for each image set. RESULTS: The A(z) value of the DWI set was larger than the SPIO set by both readers (reader 1, 0.936 vs. 0.900, P=.050; reader 2, 0.938 vs. 0.905, P=.110). For the sensitivity (reader 1, 93.1% vs. 86.2%, P=.146; reader 2, 95.4% vs. 88.5%, P=.070) and specificity (reader 1, 89.5% vs. 73.7%, P=.250; reader 2, 79.0% vs. 73.7%, P=1.000) of HCC diagnosis, DWI sets were superior to SPIO sets without statistically significant differences. CONCLUSION: For assessment of hypervascular HCC, DWI in combination with dynamic MRI provides comparable or slightly better information compared with the combination of dynamic and SPIO-enhanced MRI.
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Authors | Jin Chung, Jeong-Sik Yu, Dae Jung Kim, Jae-Joon Chung, Joo Hee Kim, Ki Whang Kim |
Journal | Magnetic resonance imaging
(Magn Reson Imaging)
Vol. 29
Issue 9
Pg. 1235-43
(Nov 2011)
ISSN: 1873-5894 [Electronic] Netherlands |
PMID | 21907517
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Contrast Media
- Ferric Compounds
- gadolinium ethoxybenzyl DTPA
- ferric oxide
- Gadolinium DTPA
|
Topics |
- Carcinoma, Hepatocellular
(pathology)
- Contrast Media
(pharmacology)
- Diffusion Magnetic Resonance Imaging
(methods)
- Ferric Compounds
(pharmacology)
- Fibrosis
(virology)
- Gadolinium DTPA
(pharmacology)
- Humans
- Liver
(pathology)
- Liver Cirrhosis
(pathology)
- Liver Neoplasms
(pathology)
- Magnetic Resonance Imaging
(methods)
- Observer Variation
- ROC Curve
- Radiology
(methods)
- Sensitivity and Specificity
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