Abstract | BACKGROUND: METHODS: Seventeen non-diabetic patients with essential hypertension who had controlled blood pressure levels using amlodipine (5 mg/day) were enrolled in this study. After randomization, either azelnidipine (16 mg/day) or amlodipine (5 mg/day) was administered in a crossover design for 12-weeks. At baseline and the end of each CCB therapy, samples of blood and urine were collected and 75 g oral glucose tolerance test (OGTT) was performed. In addition, hematopoietic progenitor cells (HPCs) were measured at each point by flow cytometry and endothelial functions were measured by fingertip pulse amplitude tonometry using EndoPAT. RESULTS: Although blood pressure levels were identical after each CCB treatment, the heart rate significantly decreased after azelnidipine administration than that after amlodipine administration (P < 0.005). Compared with amlodipine administration, azelnidipine significantly decreased levels of glucose and insulin 120 min after the 75 g OGTT (both P < 0.05). Serum levels of high-sensitivity C-reactive protein (P = 0.067) and interleukin-6 (P = 0.035) were decreased. Although endothelial functions were not different between the two medication groups, the number of circulating HPCs was significantly increased after azelnidipine administration (P = 0.016). CONCLUSIONS:
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Authors | Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 10
Pg. 79
(Sep 10 2011)
ISSN: 1475-2840 [Electronic] England |
PMID | 21906391
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Calcium Channel Blockers
- Dihydropyridines
- Amlodipine
- Azetidinecarboxylic Acid
- azelnidipine
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Topics |
- Adult
- Aged
- Amlodipine
(pharmacology, therapeutic use)
- Azetidinecarboxylic Acid
(analogs & derivatives, pharmacology, therapeutic use)
- Blood Glucose
(drug effects, metabolism)
- Calcium Channel Blockers
(pharmacology, therapeutic use)
- Cross-Over Studies
- Dihydropyridines
(pharmacology, therapeutic use)
- Endothelium, Vascular
(drug effects, metabolism, pathology)
- Female
- Humans
- Hypertension
(blood, drug therapy)
- Inflammation
(blood, drug therapy, pathology)
- Male
- Middle Aged
- Prospective Studies
- Stem Cells
(drug effects, metabolism, pathology)
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