Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to investigate the safety and tolerability of nilvadipine in AD patients. METHODS: AD patients in the intervention group (n = 56) received nilvadipine 8 mg daily over 6-weeks, compared to the control group (n = 30) who received no intervention. Differences in systolic (SBP) and diastolic (DBP) blood pressure, before and after intervention, was assessed using automated sphygmomanometer readings and ambulatory BP monitors (ABP), and change in OH using a finometer. Reporting of adverse events was monitored throughout the study. RESULTS: There was a significant reduction in the SBP of treated patients compared to non-treated patients but no significant change in DBP. Individuals with higher initial blood pressure (BP) had greater reduction in BP but individuals with normal BP did not experience much change in their BP. While OH was present in 84% of the patients, there was no further drop in BP recorded on active stand studies. There were no significant differences in adverse event reporting between groups. CONCLUSION:
Nilvadipine was well tolerated by patients with AD. This study supports further investigation of its efficacy as a potential treatment for AD.
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Authors | S P Kennelly, L Abdullah, D Paris, J Parish, V Mathura, M Mullan, F Crawford, B A Lawlor, R A Kenny |
Journal | International journal of geriatric psychiatry
(Int J Geriatr Psychiatry)
Vol. 26
Issue 10
Pg. 1038-45
(Oct 2011)
ISSN: 1099-1166 [Electronic] England |
PMID | 21905098
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright © 2010 John Wiley & Sons, Ltd. |
Chemical References |
- Antihypertensive Agents
- nilvadipine
- Nifedipine
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(drug therapy)
- Antihypertensive Agents
(adverse effects)
- Blood Pressure
(drug effects)
- Female
- Humans
- Male
- Middle Aged
- Nifedipine
(adverse effects, analogs & derivatives)
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