Impact of prohepcidin levels and iron parameters on early post-transplantation toxicities.

Abstract

OBJECTIVE:

Recent reports show the adverse impact of pre-transplantation iron overload on the outcome of haematopoietic stem cell transplantation (HSCT). We studied the pre-transplantation serum iron (SI) parameters including prohepcidin levels - a regulatory peptide of systemic iron homeostasis - and their role in early post-transplantation toxicities in allogeneic HSCT recipients.

PATIENTS AND METHODS:

One hundred consecutive patients [36 women and 64 men; median age 27·5 years (range 16-63 years)] who underwent allogeneic HSCT between September 2003 and October 2007 at Gazi University were included in the study.

RESULTS:

Pre-transplantation serum prohepcidin levels did not show correlation with SI parameters and interleukin-6 levels (P>0·05). Prohepcidin levels were inversely correlated with the National Cancer Institute grade of mucositis (P=0·060), neutropenic fever (P<0·001), and the number of days with febrile neutropenia (P=0·003). SI levels were correlated with the severity of hepatotoxicity (P=0·015) while pre-transplantation transferrin saturation levels were positively correlated with the severity of hepatotoxicity (P=0·055), pulmonary toxicity (P=0·032), and sinusoidal obstruction syndrome (P=0·049). Pre-transplantation serum ferritin levels were positively correlated with the development of sinusoidal obstruction syndrome (P=0·010) and inversely correlated with the day of neutrophil engraftment (P=0·012). Overall survival was 41·26% with a median follow-up time of 13 months (range 0·0-60 months). Pre-transplantation serum prohepcidin levels and iron overload were not associated with survival in Cox regression analysis.

CONCLUSION:

Our results suggest that pre-transplantation iron parameters and prohepcidin levels might predict some of the early post-transplantation toxicities, however, without an impact on overall survival.

• Authors: Sahika Zeynep Akı, Hatice Paşaoğlu, Zeynep Arzu Yeğin, Elif Suyanı, Canan Yılmaz Demirtaş, Zübeyde Nur Ozkurt, Münci Yağcı, Gülsan Türköz Sucak
• Journal: Hematology (Amsterdam, Netherlands) (Hematology) Vol. 16 Issue 5 Pg. 284-90 (Sep 2011) ISSN: 1607-8454 [Electronic] England
• PMID: 21902892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimicrobial Cationic Peptides
• Hepcidins
• Interleukin-6
• Protein Precursors
• C-Reactive Protein
• Ferritins
• Iron

Topics

• Adolescent
• Adult
• Antimicrobial Cationic Peptides (blood)
• C-Reactive Protein (metabolism)
• Female
• Ferritins (blood)
• Hematopoietic Stem Cell Transplantation (adverse effects, mortality)
• Hepcidins
• Humans
• Interleukin-6 (blood)
• Iron (blood)
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Protein Precursors (blood)
• Transplantation, Homologous
• Young Adult