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Impact of prohepcidin levels and iron parameters on early post-transplantation toxicities.

AbstractOBJECTIVE:
Recent reports show the adverse impact of pre-transplantation iron overload on the outcome of haematopoietic stem cell transplantation (HSCT). We studied the pre-transplantation serum iron (SI) parameters including prohepcidin levels - a regulatory peptide of systemic iron homeostasis - and their role in early post-transplantation toxicities in allogeneic HSCT recipients.
PATIENTS AND METHODS:
One hundred consecutive patients [36 women and 64 men; median age 27·5 years (range 16-63 years)] who underwent allogeneic HSCT between September 2003 and October 2007 at Gazi University were included in the study.
RESULTS:
Pre-transplantation serum prohepcidin levels did not show correlation with SI parameters and interleukin-6 levels (P>0·05). Prohepcidin levels were inversely correlated with the National Cancer Institute grade of mucositis (P=0·060), neutropenic fever (P<0·001), and the number of days with febrile neutropenia (P=0·003). SI levels were correlated with the severity of hepatotoxicity (P=0·015) while pre-transplantation transferrin saturation levels were positively correlated with the severity of hepatotoxicity (P=0·055), pulmonary toxicity (P=0·032), and sinusoidal obstruction syndrome (P=0·049). Pre-transplantation serum ferritin levels were positively correlated with the development of sinusoidal obstruction syndrome (P=0·010) and inversely correlated with the day of neutrophil engraftment (P=0·012). Overall survival was 41·26% with a median follow-up time of 13 months (range 0·0-60 months). Pre-transplantation serum prohepcidin levels and iron overload were not associated with survival in Cox regression analysis.
CONCLUSION:
Our results suggest that pre-transplantation iron parameters and prohepcidin levels might predict some of the early post-transplantation toxicities, however, without an impact on overall survival.
AuthorsSahika Zeynep Akı, Hatice Paşaoğlu, Zeynep Arzu Yeğin, Elif Suyanı, Canan Yılmaz Demirtaş, Zübeyde Nur Ozkurt, Münci Yağcı, Gülsan Türköz Sucak
JournalHematology (Amsterdam, Netherlands) (Hematology) Vol. 16 Issue 5 Pg. 284-90 (Sep 2011) ISSN: 1607-8454 [Electronic] England
PMID21902892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimicrobial Cationic Peptides
  • Hepcidins
  • Interleukin-6
  • Protein Precursors
  • C-Reactive Protein
  • Ferritins
  • Iron
Topics
  • Adolescent
  • Adult
  • Antimicrobial Cationic Peptides (blood)
  • C-Reactive Protein (metabolism)
  • Female
  • Ferritins (blood)
  • Hematopoietic Stem Cell Transplantation (adverse effects, mortality)
  • Hepcidins
  • Humans
  • Interleukin-6 (blood)
  • Iron (blood)
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Protein Precursors (blood)
  • Transplantation, Homologous
  • Young Adult

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