Abstract | BACKGROUND: METHODS: We determined the frequency of IFNγ+ CD40L+ cells/CD4+ T cells after stimulation of whole blood with pools of E. coli proteins. RESULTS: The E. coli-specific Th1 response was significantly reduced in CD patients and to a lower extent also in AS patients. CONCLUSIONS: E. coli is a target for polyclonal Th1 responses in healthy individuals. The impairment of these responses in CD and AS patients might be due to recruitment of enterobacteria-specific Th1 cells to the gut or might reflect inadequate priming of adaptive immune response.
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Authors | Asgar Ergin, Uta Syrbe, Rebecca Scheer, Andreas Thiel, Thomas Adam, Konrad Büssow, Rainer Duchmann, Martin Zeitz, Joachim Sieper |
Journal | Journal of clinical immunology
(J Clin Immunol)
Vol. 31
Issue 6
Pg. 998-1009
(Dec 2011)
ISSN: 1573-2592 [Electronic] Netherlands |
PMID | 21901394
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Escherichia coli Proteins
- CD40 Ligand
- Interferon-gamma
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Topics |
- Adaptive Immunity
- Adolescent
- Adult
- CD4-Positive T-Lymphocytes
(immunology, metabolism, pathology)
- CD40 Ligand
(metabolism)
- Cell Movement
- Child
- Child, Preschool
- Crohn Disease
(immunology, physiopathology)
- Escherichia coli Proteins
(immunology)
- Female
- Humans
- Immunosuppression Therapy
- Infant
- Inflammation
- Interferon-gamma
(metabolism)
- Intestines
(pathology)
- Male
- Spondylitis, Ankylosing
(immunology, physiopathology)
- Th1 Cells
(immunology, metabolism, pathology)
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