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[Clinical studies on cefteram pivoxil in the treatment of respiratory infections].

Abstract
Cefteram pivoxil (CFTM-PI), a new ester type cephem antibiotic, was administered at a daily dose of 600 mg to 81 patients with respiratory infections. They included 4 cases of laryngopharyngitis, 5 cases of tonsillitis, 26 cases of acute bronchitis, 13 cases of pneumonia, 10 cases of chronic bronchitis, 1 case of diffuse panbronchiolitis, 14 cases of infected bronchiectasis and 8 cases of infected other chronic respiratory diseases. Clinical effects were excellent in 18 cases, good in 50 cases, fair in 7 cases, and poor in 6 cases, thus, the efficacy rate was 84.0%. Nausea was observed in 2 cases, and diarrhea, vertigo, or fever was observed in 1 case each. The elevation of GOT and GPT values were found in 4 cases and a slight elevation of total bilirubin value was found in 1 case. These adverse reactions, however, were slight in their grades. CFTM-PI appears to be a useful oral cephem antibiotic in the treatment of respiratory infections.
AuthorsK Yamaki, H Watanabe, K Takagi, R Suzuki, T Satake, T Arai, S Matsumoto, M Hara, Y Kondo, H Taniguchi
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 43 Issue 1 Pg. 81-8 (Jan 1990) ISSN: 0368-2781 [Print] Japan
PMID2190016 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • cefteram pivoxil
  • Cefmenoxime
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Cefmenoxime (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
  • Drug Evaluation
  • Drug Resistance, Microbial
  • Female
  • Gram-Negative Bacteria (drug effects)
  • Gram-Positive Bacteria (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Respiratory Tract Infections (drug therapy, immunology)

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