Abstract |
Cefteram pivoxil (CFTM-PI), a new ester type cephem antibiotic, was administered at a daily dose of 600 mg to 81 patients with respiratory infections. They included 4 cases of laryngopharyngitis, 5 cases of tonsillitis, 26 cases of acute bronchitis, 13 cases of pneumonia, 10 cases of chronic bronchitis, 1 case of diffuse panbronchiolitis, 14 cases of infected bronchiectasis and 8 cases of infected other chronic respiratory diseases. Clinical effects were excellent in 18 cases, good in 50 cases, fair in 7 cases, and poor in 6 cases, thus, the efficacy rate was 84.0%. Nausea was observed in 2 cases, and diarrhea, vertigo, or fever was observed in 1 case each. The elevation of GOT and GPT values were found in 4 cases and a slight elevation of total bilirubin value was found in 1 case. These adverse reactions, however, were slight in their grades. CFTM-PI appears to be a useful oral cephem antibiotic in the treatment of respiratory infections.
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Authors | K Yamaki, H Watanabe, K Takagi, R Suzuki, T Satake, T Arai, S Matsumoto, M Hara, Y Kondo, H Taniguchi |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 43
Issue 1
Pg. 81-8
(Jan 1990)
ISSN: 0368-2781 [Print] Japan |
PMID | 2190016
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- cefteram pivoxil
- Cefmenoxime
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Cefmenoxime
(administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
- Drug Evaluation
- Drug Resistance, Microbial
- Female
- Gram-Negative Bacteria
(drug effects)
- Gram-Positive Bacteria
(drug effects)
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Respiratory Tract Infections
(drug therapy, immunology)
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