Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease.

Abstract

OBJECTIVES:

To determine the role of a serotonin 2A receptor gene (=HTR2A) variant in the development of impulse control and repetitive behaviors in Parkinson's disease.

METHODS:

We performed a genetic association analysis to a cohort of 404 Korean patients with Parkinson's disease who had been enrolled in a previous study. Presence of impulse control and repetitive behaviors was screened using modified version of Minnesota Impulsive Disorders Interview and genotyping for HTR2A c.102T > C was performed using the TaqMan assay.

RESULTS:

The T allele, which is presumably linked to higher receptor expression, was marginally associated with impulse control and repetitive behaviors in Parkinson's disease; the genetic influence was significantly enhanced in the lower levodopa-equivalent-dose group, increasing the risk by 2.8 and 6.9 times in CT and TT carriers, respectively (p-trend = 0.011). There was no significant interaction between the c.102T > C variant and clinical risk variables such as sex, age at onset, total daily levodopa-equivalent-dose, use of dopamine agonist and daily dose of dopamine agonist.

CONCLUSION:

Our data support a possible contribution of genetic variation in the HTR2A to the susceptibility to impulse control and repetitive behaviors in Parkinson's disease.

• Authors: Jee-Young Lee, Beom S Jeon, Han-Joon Kim, Sung-Sup Park
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 18 Issue 1 Pg. 76-8 (Jan 2012) ISSN: 1873-5126 [Electronic] England
• PMID: 21900033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Receptor, Serotonin, 5-HT2A

Topics

• Aged
• Case-Control Studies
• Cohort Studies
• Cumulative Trauma Disorders (diagnosis, epidemiology, genetics)
• Disruptive, Impulse Control, and Conduct Disorders (diagnosis, epidemiology, genetics)
• Female
• Genetic Association Studies (methods)
• Genetic Predisposition to Disease (epidemiology, genetics)
• Genetic Variation (genetics)
• Humans
• Male
• Middle Aged
• Parkinson Disease (diagnosis, epidemiology, genetics)
• Receptor, Serotonin, 5-HT2A (genetics)
• Risk Factors