HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Facial skin-lightening benefits of the tetrapeptide Pro-Lys-Glu-Lys on subjects with skin types V-VI living in South Africa.

AbstractBACKGROUND:
Irregular skin pigmentation may be a substantial contributor to the signs of aging and to a person's lack of psychological well-being. Although a large number of skin-lightening agents are available, the opportunity exists to identify more efficacious agents, agents that target alternative biological mechanisms.
AIMS:
To provide clinical evidence of the skin-lightening effect of the tetrapeptide, Pro-Lys-Glu-Lys (PKEK), on subjects with skin types V-VI living in South Africa.
METHODS:
Pro-Lys-Glu-Lys was evaluated in a double-blind and vehicle-controlled clinical study using expert grading of digital images by comparing its effects in subjects with skin types V-VI suffering from facial melasma and postinflammatory hyperpigmentation.
RESULTS:
This study demonstrated the efficacy of PKEK on subjects with skin types V-VI. On comparing the two treatments, the skin-lightening peptide-containing formulation was significantly superior to the vehicle at 12 weeks on overall appearance (P < 0.05) and evenness of skin tone (P < 0.01).
CONCLUSIONS:
The tetrapeptide, PKEK, has proven skin-lightening benefits on skin discoloration from melasma and postinflammatory hyperpigmentation. These studies have been conducted on subjects with skin types V-VI living in South Africa, but we believe this technology to be suitable for all racial groups.
AuthorsMike Farwick, Ursula Maczkiewitz, Peter Lersch, Beverley Summers, Anthony V Rawlings
JournalJournal of cosmetic dermatology (J Cosmet Dermatol) Vol. 10 Issue 3 Pg. 217-23 (Sep 2011) ISSN: 1473-2165 [Electronic] England
PMID21896134 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Copyright© 2011 Wiley Periodicals, Inc.
Chemical References
  • Dermatologic Agents
  • Oligopeptides
  • prolyl-lysyl-glutamyl-lysine
  • Glutamic Acid
  • Proline
  • Lysine
Topics
  • Adult
  • Dermatologic Agents (therapeutic use)
  • Double-Blind Method
  • Face
  • Female
  • Glutamic Acid (administration & dosage)
  • Humans
  • Lysine (administration & dosage)
  • Melanosis (drug therapy)
  • Middle Aged
  • Oligopeptides (therapeutic use)
  • Proline (administration & dosage)
  • Skin Pigmentation (drug effects)
  • South Africa
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: