Mannose-binding lectin (MBL2) polymorphisms and inflammation in hypertensive patients.

Abstract

We investigated the possible role of Mannose binding lectin 2 (MBL2) functional polymorphisms in the prevalence of hypertension and hypertensive end-organ damage in 300 hypertensive patients and 313 normotensive individuals from Southern Brazil. Hypertensive subjects with MBL2 AO/OO genotypes presented lower C-reactive protein levels than AA individuals and consequently lower inflammatory status.

• Authors: R Schreiber, A V Campos-Coelho, L Brandão, R L Guimarães, A J Kamada, M C Ferreira-Sae, J R Matos-Souza, J A Cipolli, J L de Lima-Filho, S Crovella, W Nadruz Jr
• Journal: International journal of immunogenetics (Int J Immunogenet) Vol. 38 Issue 6 Pg. 525-7 (Dec 2011) ISSN: 1744-313X [Electronic] England
• PMID: 21895981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Blackwell Publishing Ltd.

Chemical References

• MBL2 protein, human
• Mannose-Binding Lectin
• C-Reactive Protein

Topics

• Brazil
• C-Reactive Protein (metabolism)
• Female
• Genetic Predisposition to Disease
• Humans
• Hypertension (complications, genetics)
• Inflammation (complications, genetics)
• Male
• Mannose-Binding Lectin (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)