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Cytotoxicity of water-soluble fraction from biodiesel and its diesel blends to human cell lines.

Abstract
The designation of biodiesel as a green fuel has increased its commercialization and use, making its fate in the environment a matter of concern. Fuel spills constitute a major source of aquatic pollution and, like diesel spills, biodiesel can produce adverse effects on aquatic environments, animals and humans. The present study assessed cytotoxic effects of water systems contaminated with neat biodiesel and its diesel blends by means of different procedures on human T cell leukemia (Jurkat) and human hepatocellular carcinoma (HepG2) cells [detection of changes in mitochondrial membrane potential (ΔΨ(m)) using tetramethylrhodamine ethyl ester (TMRE), apoptosis recognition by Annexin V and impedance real-time cell analyzer (xCELLigence™ system)]. The data obtained showed concordance across the different bioassays, with cytotoxic effects observed as a dose-dependent response only for waters contaminated with pure diesel (D100) and B5 blend, which is characterized by a mixture of 95% diesel and 5% biodiesel. The data can also lead us to hypothesize that diesel accounts for the harmful effects observed, and that biodiesel does not worsen the impacts caused by diesel pollution.
AuthorsDaniela Morais Leme, Tamara Grummt, Rita Heinze, Andrea Sehr, Matthias Skerswetat, Mary Rosa Rodrigues de Marchi, Marcos Canto Machado, Danielle Palma de Oliveira, Maria Aparecida Marin-Morales
JournalEcotoxicology and environmental safety (Ecotoxicol Environ Saf) Vol. 74 Issue 8 Pg. 2148-55 (Nov 2011) ISSN: 1090-2414 [Electronic] Netherlands
PMID21889212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Biofuels
  • Cytotoxins
  • Gasoline
  • Water Pollutants, Chemical
Topics
  • Biofuels (toxicity)
  • Cell Line
  • Cytotoxins (chemistry, toxicity)
  • Environmental Pollution
  • Gasoline (toxicity)
  • Humans
  • Solubility
  • Water Pollutants, Chemical (chemistry, toxicity)

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