Abstract | PURPOSE: METHODS: : Two choroideremia patients with cystoid macular edema, observed by spectral-domain optical coherence tomography, were treated with a topical form of carbonic anhydrase inhibitor. Examinations performed before and during treatment included best-corrected visual acuity by using the Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity measured with briefly presented grating targets and the Pelli-Robson letter contrast sensitivity chart, microperimetry, and spectral-domain optical coherence tomography. RESULTS: : The 2 choroideremia patients treated with dorzolamide 2% formulation had a noticeable reduction in macular thickness by spectral-domain optical coherence tomography. This reduction was found in both eyes after 2 months of treatment. After an additional 3 months of the same treatment regimen, a more noticeable reduction in macular thickness was observed. The two study patients had improvement of their visual acuity, in at least one eye, on Early Treatment Diabetic Retinopathy Study charts, but no clinically significant changes for the other measures of visual function. CONCLUSION:
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Authors | Mohamed A Genead, Jason J McAnany, Gerald A Fishman |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 32
Issue 4
Pg. 826-33
(Apr 2012)
ISSN: 1539-2864 [Electronic] United States |
PMID | 21886018
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbonic Anhydrase Inhibitors
- Sulfonamides
- Thiophenes
- dorzolamide
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Topics |
- Carbonic Anhydrase Inhibitors
(administration & dosage)
- Choroideremia
(complications)
- Contrast Sensitivity
(physiology)
- Humans
- Macular Edema
(drug therapy, physiopathology)
- Male
- Middle Aged
- Sulfonamides
(administration & dosage)
- Thiophenes
(administration & dosage)
- Tomography, Optical Coherence
- Treatment Outcome
- Visual Acuity
(physiology)
- Visual Field Tests
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