Abstract | OBJECTIVE:
Lumican (LUM) is predominantly localized in areas of pathological fibrosis. To determine whether polymorphisms in LUM gene are associated with development of systemic lupus erythematosus (SLE), we analyzed 2 single-nucleotide polymorphisms (SNP) of LUM in a Taiwan Chinese Han population. METHODS: Participants included 168 patients with SLE and 192 age-matched controls in whom examinations had excluded SLE. Genotyping of -628 A/-(rs17018757) and c.1567 T/C polymorphisms in LUM were carried out in each patient and control using the polymerase chain reaction-restriction fragment-length polymorphism method, and validated by Taqman SNP genotyping assay. Data were correlated with the development of SLE and various clinical symptoms by chi-square analysis. RESULTS: Frequencies of C/C genotype and the C allele at c.1567 T/C were significantly higher in patients than controls. Polymorphism at c.1567 C/T was found to be associated with arthritis and photosensitivity in patients with SLE, which are both connective tissue-related symptoms. CONCLUSION: The c.1567 T/C polymorphism of LUM is related to the development and clinical symptoms of SLE.
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Authors | Pei-Chun Chang, Yi Chen, Ming-Tsong Lai, Heng-Yuan Chang, Chung-Ming Huang, Hsin-Ping Liu, Wei-Yong Lin, Chih-Ho Lai, Jim Jinn-Chyuan Sheu, Fuu-Jen Tsai |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 38
Issue 11
Pg. 2376-81
(Nov 2011)
ISSN: 0315-162X [Print] Canada |
PMID | 21885486
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chondroitin Sulfate Proteoglycans
- LUM protein, human
- Lumican
- Keratan Sulfate
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Topics |
- Asian People
(genetics)
- Case-Control Studies
- Chondroitin Sulfate Proteoglycans
(genetics)
- Gene Frequency
(genetics)
- Genetic Linkage
(genetics)
- Genetic Predisposition to Disease
(ethnology, genetics)
- Genotype
- Humans
- Keratan Sulfate
(genetics)
- Lumican
- Lupus Erythematosus, Systemic
(ethnology, genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Taiwan
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