Twenty years of clinical experience with a new modality of vascular-targeted photodynamic therapy for port wine stains.

Abstract

BACKGROUND:

Port wine stains (PWS) are congenital capillary malformations of the skin and are difficult to treat without scarring. Since January 1991, our group has performed a new modality of vascular-targeted photodynamic therapy (PDT) for PWS treatment.

OBJECTIVE:

To summarize our clinical experiences with vascular-targeted PDT for PWS at Chinese PLA General Hospital.

METHODS AND MATERIALS:

Our group has collected and reviewed retrospective clinical research data of vascular-targeted PDT for treating PWS since January 1991.

RESULTS:

Clinical studies showed that vascular-targeted PDT is an effective treatment for all types of PWS. Repetitive treatment sessions were usually needed to obtain a better cosmetic effect. No recurrence was seen in patients followed up for longer than 19 years. There were no significant side effects or adverse reactions.

CONCLUSION:

This new PDT is an effective, safe, and noninvasive modality with no recurrence for PWS, although the protocol for PDT requires further optimization.

• Authors: Haixia Qiu, Ying Gu, Ying Wang, Naiyan Huang
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 37 Issue 11 Pg. 1603-10 (Nov 2011) ISSN: 1524-4725 [Electronic] United States
• PMID: 21883647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 by the American Society for Dermatologic Surgery, Inc.

Chemical References

• Photosensitizing Agents

Topics

• Adult
• Asian People
• Female
• Humans
• Laser Therapy
• Male
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Port-Wine Stain (drug therapy)
• Therapeutics