Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I.

Abstract

Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.

• Authors: Anna Caruso, Adele Chimento, Hussein El-Kashef, Jean-Charles Lancelot, Antonella Panno, Vincenzo Pezzi, Carmela Saturnino, Maria Stefania Sinicropi, Rosa Sirianni, Sylvain Rault
• Journal: Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem) Vol. 27 Issue 4 Pg. 609-13 (Aug 2012) ISSN: 1475-6374 [Electronic] England
• PMID: 21883039 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carbazoles
• Receptors, Estrogen

Topics

• Adult
• Aged
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Breast Neoplasms (drug therapy, metabolism, pathology)
• Carbazoles (chemical synthesis, chemistry, pharmacology)
• Carcinoma, Endometrioid (drug therapy, metabolism, pathology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Endometrial Neoplasms (drug therapy, metabolism, pathology)
• Female
• Humans
• Molecular Structure
• Receptors, Estrogen (metabolism)
• Stereoisomerism
• Structure-Activity Relationship