Enhancement of energy expenditure and reducing energy intake are crucial for weight control.
Capsiate, a non-pungent
capsaicin analog, is known to suppress body fat accumulation and reduce
body weight by enhancing of energy expenditure in both mice and humans. However, it is poorly understood whether suppressing body fat accumulation by
capsiate administration is equal to exercise or not. The aim of this study is to compare the effects of repeated administration of
capsiate and exercise and to investigate the weight rebound after repeated
capsiate administration and/or exercise. In the present study, we report that 2 weeks treatment of
capsiate and exercise increased energy metabolism and suppressed body fat accumulation during 4 more weeks of ad libitum feeding. The
body weight in
capsiate and exercise groups was significantly lower than that of control group. The oxygen consumption was significanlty increased in
capsiate and exercise groups than in the vehicle administered mice. In addition, the abdominal adipose tissue weight in
capsiate and exercise groups was significantly lower than that of control group. These results indicate that suppressing body fat accumulation by
capsiate intake is beneficial for maintaining an ideal body weight as exercise.