Renal effects of the non-ionic contrast medium iopentol after intravenous injection in healthy volunteers.

Abstract

Renal effects of the new non-ionic contrast medium iopentol in increasing doses were assessed and compared with the effects of physiologic saline. Twenty-four healthy male volunteers, allocated to three dose groups, were given iopentol intravenously in doses of 0.3, 0.6, and 1.2 g I/kg body weight, respectively. The highest dose group was also given physiologic saline separately as a control. The diuresis increased in all groups, most in the highest dose group, and with a concomitant fall of urine osmolality and increase in osmolar clearance. A slight decrease of serum osmolality, creatinine and urea occurred at 3 hours due to hemodilution. The glomerular filtration rate was unaffected by iopentol. The urinary excretion of albumin and beta 2-microglobulin was unchanged. However, urinary N-acetyl-beta-glucosaminidase and alkaline phosphatase increased significantly, most in the highest dose group. All changes were reversible.

• Authors: J A Jakobsen, K J Berg, A Waaler, E Andrew
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 31 Issue 1 Pg. 87-91 (Jan 1990) ISSN: 0284-1851 [Print] England
• PMID: 2187515 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Iodobenzoates
• Triiodobenzoic Acids
• beta 2-Microglobulin
• iopentol
• Urea
• Creatinine
• Acetylglucosaminidase

Topics

• Acetylglucosaminidase (urine)
• Adult
• Albuminuria
• Contrast Media (administration & dosage, pharmacology)
• Creatinine (blood, urine)
• Humans
• Injections, Intravenous
• Iodobenzoates (pharmacology)
• Kidney (drug effects)
• Kidney Function Tests
• Male
• Osmolar Concentration
• Triiodobenzoic Acids (administration & dosage, pharmacology)
• Urea (blood, urine)
• Urine
• beta 2-Microglobulin (urine)