Auto bi-level pressure relief-PAP is as effective as CPAP in OSA patients--a pilot study.

Continuous positive airway pressure (CPAP) is the therapy of choice for the treatment of obstructive sleep apnea (OSA). Not all patients can use CPAP therapy with adequate compliance. There is a need to develop more comfortable modes. Auto bi-level Pressure Relief-Positive Airway Pressure (ABPR-PAP) can be an alternative. We conducted a prospective double-blind, randomised trial to evaluate the efficacy and compliance of ABPR-PAP compared with CPAP in OSA patients.
We included 35 CPAP naive patients (age 53.3 ± 10.3 years, BMI 31.0 ± 5.0 kg/m(2), ESS 10.0 ± 4.2) diagnosed with moderate to severe OSA who underwent a successful CPAP titration. Patients were randomised into the CPAP or the ABPR-PAP treatment group. We used the same device (BIPAP® Auto, Philips Respironics) for CPAP or ABPR-PAP. Apnea-hypopnea index (AHI) was determined using polysomnography before (AHI 40.6 ± 18.3 per hour) and after treatment.
Eighteen patients received CPAP and the remaining 17 received APBR-PAP. Groups were similar in terms of demographics and OSA severity. There were no serious adverse events during the trial. CPAP was fixed by a sleep expert and ABPR-PAP varied (range 5-15 cmH(2)O). AHI decreased in the CPAP group to 6.4 ± 5.7 per hour and in the ABPR-PAP group to 4.8 ± 3.6 per hour in the first night (N = 35). After 3 months, the AHI decreased in the CPAP group to 4.4 ± 5.3 per hour and in the ABPR-PAP group to 2.6 ± 3.8 per hour (N = 32). Differences between the groups were not statistically significant. There were no differences in compliance.
ABPR-PAP is a promising new ventilation mode that enables effective treatment of OSA patients.
AuthorsAlexander Blau, Mihaela Minx, Jan Giso Peter, Martin Glos, Thomas Penzel, Gert Baumann, Ingo Fietze
JournalSleep & breathing = Schlaf & Atmung (Sleep Breath) Vol. 16 Issue 3 Pg. 773-9 (Sep 2012) ISSN: 1522-1709 [Electronic] Germany
PMID21874370 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
  • Adult
  • Aged
  • Continuous Positive Airway Pressure (instrumentation, methods)
  • Double-Blind Method
  • Equipment Design
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Pilot Projects
  • Polysomnography
  • Prospective Studies
  • Sleep Apnea, Obstructive (diagnosis, therapy)
  • Sleep Stages (physiology)
  • Therapy, Computer-Assisted (instrumentation, methods)

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