High serum level of lutein may be protective against early atherosclerosis: the Beijing atherosclerosis study.

Abstract

OBJECTIVE:

We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness.

METHODS:

The case-control study comprised 125 subjects with early atherosclerosis and 107 controls aged 45-68 years. We simultaneously measured common carotid IMT and arterial stiffness by carotid ultrasonography, and serum carotenoids were determined by high-pressure liquid chromatograph (HPLC).

RESULTS:

In cases of early atherosclerosis, serum level of lutein was significantly lower than that in controls. Serum lutein was inversely associated with carotid IMT. Zeaxanthin and β-carotene were both negatively correlated with right common carotid artery stiffness β, elastic modulus (E(p)), and pulse wave velocity (PWV). After adjusting for age and gender, the associations remain significantly (P<0.05). However, there is no significant difference for zeaxanthin and β-carotene between the cases and controls.

CONCLUSION:

These findings suggest that lutein may play a protective role in the prevention of early atherosclerosis, and the associations between serum carotenoids and arterial stiffness remained to be investigated.

• Authors: Zhiyong Zou, Xianrong Xu, Yangmu Huang, Xin Xiao, Le Ma, Tingting Sun, Pengcheng Dong, Xun Wang, Xiaoming Lin
• Journal: Atherosclerosis (Atherosclerosis) Vol. 219 Issue 2 Pg. 789-93 (Dec 2011) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 21872250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Xanthophylls
• Zeaxanthins
• beta Carotene
• Carotenoids
• Lycopene
• Lutein

Topics

• Aged
• Carotenoids (blood)
• Carotid Artery Diseases (blood, diagnostic imaging, physiopathology, prevention & control)
• Carotid Artery, Common (diagnostic imaging, physiopathology)
• Case-Control Studies
• Chi-Square Distribution
• China
• Early Diagnosis
• Elasticity
• Female
• Humans
• Lutein (blood)
• Lycopene
• Male
• Middle Aged
• Predictive Value of Tests
• Tunica Intima (diagnostic imaging)
• Tunica Media (diagnostic imaging)
• Ultrasonography
• Up-Regulation
• Xanthophylls (blood)
• Zeaxanthins
• beta Carotene (blood)