Ovarian cancer during pregnancy.

Abstract

OBJECTIVE:

To evaluate the clinical features, pregnancy outcome, and treatment of patients with ovarian cancer diagnosed during pregnancy.

METHODS:

The present study was a retrospective review of 11 cases of ovarian cancer detected during pregnancy. The women were treated and followed up at Selçuk University, Meram Faculty of Medicine, Konya, Turkey, during 2006-2010.

RESULTS:

Approximately half the patients were asymptomatic (5 [45.5%]) and diagnosed during cesarean delivery (6 [54.5%]). The histopathologic tumor categories comprised malignant epithelial ovarian tumor (4 [36.4%]), borderline tumor (4 [36.4%]), malignant germ cell tumor (2 [18.2%]), and sex cord stromal tumor (1 [9.1%]). Nine (81.8%) tumors were classified as stage I. Conservative surgery was performed in 10 (90.9%) patients. A patient with stage IIIC serous papillary adenocarcinoma underwent hysterectomy with bilateral salpingo-oophorectomy. A patient with dysgerminoma in stage IV died on follow-up. Three infants were born premature; they were followed up in the neonatal intensive care unit with satisfactory outcomes.

CONCLUSION:

Early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. Tumor staging is possible during pregnancy, but the appropriateness of surgery needs to be considered carefully. Ideally, the treatment strategy should be discussed and structured on an individual basis.

• Authors: Kazım Gezginç, Rengin Karataylı, Fatma Yazıcı, Ali Acar, Cetin Celik, Metin Capar
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 115 Issue 2 Pg. 140-3 (Nov 2011) ISSN: 1879-3479 [Electronic] United States
• PMID: 21872237 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents

Topics

• Adult
• Antineoplastic Agents (administration & dosage)
• Carcinoma, Ovarian Epithelial
• Cesarean Section
• Combined Modality Therapy
• Female
• Humans
• Hysterectomy
• Neoplasm Staging
• Neoplasms, Germ Cell and Embryonal (diagnosis, epidemiology, pathology, therapy)
• Neoplasms, Glandular and Epithelial (diagnosis, epidemiology, pathology, therapy)
• Ovarian Neoplasms (diagnosis, epidemiology, pathology, therapy)
• Ovariectomy
• Pregnancy
• Pregnancy Complications, Neoplastic (diagnosis, epidemiology, pathology, therapy)
• Pregnancy Outcome
• Prenatal Diagnosis
• Retrospective Studies
• Sex Cord-Gonadal Stromal Tumors (diagnosis, epidemiology, pathology, therapy)
• Turkey (epidemiology)
• Young Adult