HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid--a case report.

Abstract
This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). Treatment started with the cholesterol lowering drug, atorvastatin, followed by add-on therapy with Lorenzo's oil (LO) and finally supplementation with docosahexaenoic acid (DHA). The magnetic resonance imaging (MRI) scan of the AMN patient before DHA treatment, already showed abnormal white matter in the brain. Although the MRI showed no neurological improvement after 6 months of DHA treatment, no selective progression of demyelination was detected in the AMN patient. Contrary to what was expected, LO failed to sustain or normalize the VLCFA levels or improve clinical symptoms. It was however, shown that DHA supplementation in addition to LO, increased DHA levels in both plasma and red blood cells (RBC). Additionally, the study showed evidence that the elongase activity in the elongation of eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA) might have been significantly compromised, due to the increased DHA levels.
AuthorsGisella Terre'Blanche, Mietha M van der Walt, Jacobus J Bergh, Lodewyk J Mienie
JournalLipids in health and disease (Lipids Health Dis) Vol. 10 Pg. 152 (Aug 26 2011) ISSN: 1476-511X [Electronic] England
PMID21871076 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticholesteremic Agents
  • Drug Combinations
  • Erucic Acids
  • Heptanoic Acids
  • Hypolipidemic Agents
  • Lorenzo's oil
  • Pyrroles
  • Triolein
  • Docosahexaenoic Acids
  • Atorvastatin
Topics
  • Adrenoleukodystrophy (blood, diet therapy, drug therapy, physiopathology)
  • Adult
  • Anticholesteremic Agents (therapeutic use)
  • Atorvastatin
  • Combined Modality Therapy
  • Dietary Supplements
  • Disease Progression
  • Docosahexaenoic Acids (blood, therapeutic use)
  • Drug Combinations
  • Drug Therapy, Combination
  • Erucic Acids (therapeutic use)
  • Heptanoic Acids (therapeutic use)
  • Humans
  • Hypolipidemic Agents (therapeutic use)
  • Male
  • Pyrroles (therapeutic use)
  • Treatment Outcome
  • Triolein (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: