Acne vulgaris is one of the most common dermatological diseases, and caused by a combination of pathogenetic factors including follicular hyperkeratosis,
seborrhea, colonization with Propionibacteriumacnes and inflammatory phenomena. Various medical treatments address these causative factors, but they are not always well tolerated. In the last decades, there has been increased interest in
laser and light-based treatments. These
optical devices mainly target Propionibacteriumacnes by activating
porphyrins produced by the bacterium, whereas some treatments directly lead to the destruction of sebaceous glands.
Photodynamic therapy can enhance these effects through the prior application of a
photosensitizing agent. Many
laser and light-based treatments have shown excellent clinical results in the reduction of inflammatory
acne lesions and improved
acne severity. Although relapses are frequent, results can be improved by combination
therapy with conventional medical treatments. Data of randomized controlled studies or studies with a split-face design are contradictory and difficult to compare. Furthermore, the cost of the treatments is often a limiting factor. In summary, some
optical devices are an important additional tool in the treatment of patients with mainly inflammatory
acne where conventional treatments are not well tolerated.