Abstract | PURPOSE: To investigate the protein expression of Twist, Snail, and Slug in oral squamous cell carcinoma (OSCC) samples and evaluate the potential correlation between the expression status and clinicopathologic features in patients with OSCC. PATIENTS AND METHODS: Twist, Snail, and Slug protein expression was assessed by immunohistochemistry in a total of 60 OSCC samples and 10 normal oral mucosal samples. The associations between the protein expression and clinicopathologic parameters were mainly detected using the χ(2) test. The survival analysis was performed using the Kaplan-Meier method, and the prognostic analysis was performed using Cox regression models. RESULTS: Immunohistochemistry stain analysis showed that positive Twist, Snail, and Slug protein expression was observed in 70%, 63.3%, and 58.3% of the cases, respectively. Twist protein expression was positively associated with lymph node metastasis, pathologic grade, and tumor stage (P = .012, P = .008, and P = .004, respectively, χ(2) test). All patients were followed up for 6 to 59 months (mean 37). A correlation between Twist protein expression and tumor recurrence was detected (log-rank test, P = .025). Nevertheless, no correlation was found between the Snail and Slug protein expression and the clinicopathologic parameters. CONCLUSIONS:
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Authors | Alimujiang Wushou, Hong-Ya Pan, Wei Liu, Zhen Tian, Li-Zhen Wang, Shalamati Shali, Zhi-Yuan Zhang |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 70
Issue 6
Pg. 1473-9
(Jun 2012)
ISSN: 1531-5053 [Electronic] United States |
PMID | 21864967
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- SNAI1 protein, human
- Snail Family Transcription Factors
- Transcription Factors
- Twist-Related Protein 1
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Topics |
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
(metabolism, pathology, secondary)
- Chi-Square Distribution
- China
- Female
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Male
- Middle Aged
- Mouth Neoplasms
(metabolism, pathology)
- Neoplasm Grading
- Neoplasm Recurrence, Local
(metabolism)
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Snail Family Transcription Factors
- Transcription Factors
(biosynthesis)
- Twist-Related Protein 1
(biosynthesis)
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