Abstract | OBJECTIVE: METHODS: RESULTS: Among 57 patients (58% with Stage IV and hypopharyngeal cancer), the rates of Grade 3-4 toxicity were 30 and 74% during induction and CCRT, respectively. A total of 49 patients completed induction and began concurrent chemoradiation; 47 (96%) completed all planned treatment. With a median follow-up of 62 months (range 19-83 months) for the current survivors, the 3-year overall and disease-specific survival estimates were 50 and 58%, respectively. The 3-year organ preservation survival was 74% in patients who achieved complete remission after concurrent chemoradiation, and 96% of current survivors are tracheotomy and feeding tube-free. No patient without local/regional failure suffered from distant metastasis. CONCLUSIONS:
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Authors | Tung-Lung Tsai, Pen-Yuan Chu, Shyh-Kuan Tai, Yi-Fen Wang, Muh-Hwa Yang, Ling-Wei Wang, Jiing-Feng Lirng, Shyue-Yih Chang |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 41
Issue 10
Pg. 1182-93
(Oct 2011)
ISSN: 1465-3621 [Electronic] England |
PMID | 21862506
(Publication Type: Journal Article)
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Chemical References |
- Cisplatin
- Fluorouracil
- Methotrexate
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carcinoma, Squamous Cell
(drug therapy, radiotherapy)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage)
- Head and Neck Neoplasms
(drug therapy, radiotherapy)
- Humans
- Male
- Methotrexate
(administration & dosage, adverse effects)
- Middle Aged
- Quality of Life
- Radiotherapy
(adverse effects)
- Remission Induction
- Retrospective Studies
- Survival Analysis
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