HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Randomized controlled trial assessing efficacy and safety of glycine powder air polishing in moderate-to-deep periodontal pockets.

AbstractBACKGROUND:
Supragingivally applied glycine powder air polishing (SupraGPAP) has been shown to remove biofilms in shallow periodontal pockets. This study assesses efficacy and safety of subgingivally applied glycine powder air polishing (SubGPAP) in moderate-to-deep periodontal pockets.
METHODS:
Patients with chronic periodontitis and intraoral Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia who completed initial therapy were randomly assigned to receive SubGPAP in periodontal pockets with probing depths of 4 to 9 mm, SupraGPAP in all other shallow periodontal sites, and at mucous membranes followed by removal of calculus using curets (full-mouth GPAP) or scaling and root planing followed by coronal polishing (SRP). Patients rinsed with 0.12% chlorhexidine gluconate after debridement, and twice daily, for 2 weeks.
RESULTS:
All 30 patients enrolled completed the baseline, day 10, and day 90 visits. SubGPAP resulted in significantly lower total viable bacterial counts in moderate-to-deep pockets when compared to SRP immediately after debridement and at day 10 (P <0.05). Total P. gingivalis counts in the oral cavity were significantly reduced after full-mouth GPAP compared to SRP at day 90 (P <0.05). Patients' comfort levels were high for both treatments. There were no adverse events related to full-mouth GPAP.
CONCLUSIONS:
The results indicate that SubGPAP is more efficacious in removing subgingival biofilm in moderate-to-deep periodontal pockets than SRP. Furthermore, full-mouth GPAP may result in a beneficial shift of the oral microbiota and appears to be well tolerated.
AuthorsThomas F Flemmig, Daniyel Arushanov, Diane Daubert, Marilynn Rothen, Gregory Mueller, Brian G Leroux
JournalJournal of periodontology (J Periodontol) Vol. 83 Issue 4 Pg. 444-52 (Apr 2012) ISSN: 1943-3670 [Electronic] United States
PMID21861637 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents, Local
  • Glycine Agents
  • Mouthwashes
  • Powders
  • chlorhexidine gluconate
  • Chlorhexidine
  • Glycine
Topics
  • Adult
  • Aged
  • Anti-Infective Agents, Local (therapeutic use)
  • Bacterial Load
  • Bacteroidaceae Infections (therapy)
  • Bacteroides (isolation & purification)
  • Biofilms
  • Chlorhexidine (analogs & derivatives, therapeutic use)
  • Chronic Periodontitis (microbiology, therapy)
  • Dental Calculus (therapy)
  • Dental Prophylaxis (methods)
  • Dental Scaling (instrumentation, methods)
  • Female
  • Follow-Up Studies
  • Glycine (therapeutic use)
  • Glycine Agents (therapeutic use)
  • Humans
  • Male
  • Microbial Viability
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Patient Satisfaction
  • Periodontal Pocket (microbiology, therapy)
  • Porphyromonas gingivalis (isolation & purification)
  • Powders
  • Root Planing (methods)
  • Safety
  • Subgingival Curettage (methods)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: