Development of acute megakaryoblastic leukemia with isochromosome (12p) after a primary mediastinal germ cell tumor in Korea.

Abstract

The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.

• Authors: Nae Yu, Hye Ryoun Kim, Young-Joo Cha, Eun Kyung Park, Jeong Wook Kim
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 26 Issue 8 Pg. 1099-102 (Aug 2011) ISSN: 1598-6357 [Electronic] Korea (South)
• PMID: 21860563 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bleomycin
• Etoposide
• Cisplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Bone Marrow (pathology)
• Chromosomes, Human, Pair 12
• Cisplatin (administration & dosage)
• Etoposide (administration & dosage)
• Humans
• Isochromosomes
• Karyotyping
• Leukemia, Megakaryoblastic, Acute (drug therapy, etiology, genetics)
• Male
• Mediastinal Neoplasms (diagnosis, drug therapy, surgery)
• Neoplasms, Germ Cell and Embryonal (diagnosis, drug therapy, surgery)
• Neoplasms, Second Primary (drug therapy, etiology, genetics)
• Republic of Korea
• Shock, Septic (pathology)