Abstract | BACKGROUND: OBJECTIVE: METHODS: A prospective observational study was undertaken. Two patients with MA started continuous treatment with anakinra (1-2 mg/kg/day) and nine patients with HIDS chose between continuous treatment and on-demand treatment (starting at first symptoms of attack, 100 mg/day or 1 mg/kg/day for 5-7 days). RESULTS:
Anakinra induced partial remission in one patient with MA but there was no response in the other patient with MA. In one patient with HIDS continuous treatment induced complete remission for 7 months but was stopped because of side effects. Eight patients with HIDS preferred on-demand treatment from the start. This induced a clinical response (≥50% reduction in duration) in 8 of 12 treated attacks without a change in attack frequency. Anakinra prevented fever attacks due to vaccination without inhibiting antibody induction. No major side effects were seen. CONCLUSIONS: On-demand treatment with anakinra in HIDS decreases the duration and severity of fever attacks. Because of the burden of daily injections and relatively long asymptomatic intervals of HIDS, all patients with HIDS preferred on-demand treatment.
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Authors | E J Bodar, L M Kuijk, J P H Drenth, J W M van der Meer, A Simon, J Frenkel |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 70
Issue 12
Pg. 2155-8
(Dec 2011)
ISSN: 1468-2060 [Electronic] England |
PMID | 21859689
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Interleukin 1 Receptor Antagonist Protein
- C-Reactive Protein
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Topics |
- Adolescent
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- C-Reactive Protein
(metabolism)
- Child
- Child, Preschool
- Drug Administration Schedule
- Female
- Fever
(drug therapy, etiology)
- Humans
- Interleukin 1 Receptor Antagonist Protein
(administration & dosage, therapeutic use)
- Male
- Mevalonate Kinase Deficiency
(blood, complications, drug therapy)
- Prospective Studies
- Treatment Outcome
- Young Adult
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