Abstract | BACKGROUND: METHODS: RESULTS: In the pilot study, the SNP (rs769236) was associated significantly with the risk of lung cancer. In the expanded study, multivariate logistic regression indicated that the AA homozygous variant of the SNP was associated significantly with the development of lung cancer (P < .0001; codominant model), colorectal cancer (P < .0001), and hepatocellular carcinoma (P = .02) but not with breast cancer or gastric cancer. The luciferase activity of a 300-base pair construct that contained the A allele was 1.5-fold greater than the activity of a construct with the G allele in NIH3T3 cells. The high luciferase activity of constructs that contained the A allele did not change with cell cycle progression. CONCLUSIONS: The current results suggested that an SNP (rs769236) at the promoter of CCNA2 may be associated significantly with increased risk of colon, liver, and lung cancers.
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Authors | Duk-Hwan Kim, Seong-Eun Park, Minseung Kim, Yong Ick Ji, Mi Yeon Kang, Eun Hyun Jung, Eunkyung Ko, Yujin Kim, Sung Kim, Young Mog Shim, Joobae Park |
Journal | Cancer
(Cancer)
Vol. 117
Issue 17
Pg. 4080-91
(Sep 01 2011)
ISSN: 1097-0142 [Electronic] United States |
PMID | 21858804
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Cancer 2011 © 2011 American Cancer Society. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Case-Control Studies
- Colorectal Neoplasms
(genetics)
- Cyclin A2
(genetics)
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Liver Neoplasms
(genetics)
- Lung Neoplasms
(genetics)
- Mice
- NIH 3T3 Cells
- Pilot Projects
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Risk
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