Abstract |
Plasma lipid peroxides were measured as malonyldialdehyde (MDA) by the thiobarbituric acid (TBA) method in 75 children suffering from Plasmodium falciparum malaria. Their riboflavin status was assessed by measuring erythrocyte glutathione reductase activation coefficients (EGRACs), and values greater than 1.40 were regarded as indicating biochemical deficiency. Plasma MDA was higher (p less than 0.001) in patients than in control subjects; the concentrations were 3.65 +/- 0.70 and 1.77 +/- 0.45 mumol/L (means +/- SD), respectively. The riboflavin-deficient group had higher plasma MDA values (3.98 +/- 0.70 mumol/L) than did the nondeficient group (3.30 +/- 0.68 mumol/L, p less than 0.001). Plasma MDA concentrations correlated with EGRACs (r = 0.46, p less than 0.01) in the patients. It is proposed that riboflavin deficiency restricts regeneration of reduced glutathione making the parasitized erythrocytes more vulnerable to destructive lipid peroxidation and increasing plasma lipid hydroperoxides.
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Authors | B S Das, D I Thurnham, J K Patnaik, D B Das, R Satpathy, T K Bose |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 51
Issue 5
Pg. 859-63
(May 1990)
ISSN: 0002-9165 [Print] United States |
PMID | 2185624
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Malonates
- Malondialdehyde
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Topics |
- Animals
- Child
- Child, Preschool
- Humans
- Infant
- Lipid Peroxidation
- Malaria
(complications)
- Malonates
(blood)
- Malondialdehyde
(blood)
- Plasmodium falciparum
- Riboflavin Deficiency
(blood, complications)
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