Abstract | PURPOSE: MATERIALS AND METHODS: In female nulliparous Sprague-Dawley® rats under urethane anesthesia after ovariectomy with or without estrogen replacement we measured urethral response amplitude during sneezing, urethral baseline pressure and sneeze induced leak point pressure. Whole urethras were tested for ex vivo urethral properties. RESULTS: Urethral response amplitude during sneezing was significantly decreased in 3 and 6-week ovariectomized rats. Urethral baseline pressure was significantly decreased only in 6-week ovariectomized rats. After estrogen replacement urethral baseline pressure but not urethral response amplitude during sneezing was significantly increased. Neither 3-week ovariectomized nor sham operated rats leaked during sneezing but fluid leakage was observed in 63% of 6-week ovariectomized rats. Estrogen replacement decreased the stress urinary incontinence incidence to 25%. Ex vivo testing revealed a significant increase in middle urethral compliance and a decrease in β stiffness at the proximal and middle urethras in 6-week ovariectomized rats. CONCLUSIONS:
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Authors | Takeya Kitta, Donna J Haworth-Ward, Minoru Miyazato, Masashi Honda, William C de Groat, Katsuya Nonomura, David A Vorp, Naoki Yoshimura |
Journal | The Journal of urology
(J Urol)
Vol. 186
Issue 4
Pg. 1517-23
(Oct 2011)
ISSN: 1527-3792 [Electronic] United States |
PMID | 21855912
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Topics |
- Animals
- Estrogen Replacement Therapy
- Female
- In Vitro Techniques
- Menopause
(physiology)
- Ovariectomy
- Pressure
- Rats
- Rats, Sprague-Dawley
- Reflex
(physiology)
- Sneezing
(physiology)
- Urethra
(physiopathology)
- Urinary Bladder
(physiopathology)
- Urinary Incontinence, Stress
(physiopathology)
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