Corifollitropin alfa: a new option to treat female infertility.

Abstract

Corifollitropin alfa (Elonva®) is the first hybrid follicle-stimulating hormone (FSH) molecule with demonstrated sustained follicle-stimulating activity. The β subunit of this molecule contains the carboxy-terminal peptide of human chorionic gonadotropin, which alters the pharmacokinetic profile of the molecule. It demonstrates a longer circulation half-life and extended time to peak levels when compared with recombinant FSH (rFSH). Like rFSH, it lacks luteinizing hormone activity and binds specifically to the FSH receptor in vitro. Clinical trials show that corifollitropin alfa is able to sustain multiple follicular growth for a week, with a similar ovarian response and safety profile as rFSH. A single injection of corifollitropin alfa can replace 7 daily injections of rFSH during the first week of ovarian stimulation in gonadotropin-releasing hormone antagonist protocols. Therefore, corifollitropin alfa addresses the need for a simplified treatment approach to lessen the burden of multiple daily injections for in vitro fertilization.

• Authors: Jane de Lartigue
• Journal: Drugs of today (Barcelona, Spain : 1998) (Drugs Today (Barc)) Vol. 47 Issue 8 Pg. 583-90 (Aug 2011) ISSN: 1699-3993 [Print] Spain
• PMID: 21850281 (Publication Type: Journal Article)
• Copyright: Copyright 2011 Prous Science, S.A.U. or its licensors. All rights reserved.

Chemical References

• Follicle Stimulating Hormone, Human
• follicle stimulating hormone, human, with HCG C-terminal peptide
• Follicle Stimulating Hormone

Topics

• Clinical Trials as Topic
• Female
• Follicle Stimulating Hormone (therapeutic use)
• Follicle Stimulating Hormone, Human (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Humans
• Infertility, Female (drug therapy)