Abstract | PURPOSE: METHODS: RESULTS: αB- crystallin expression in breast cancer tissues was associated with PR (p=0.030), the number of metastatic lymph nodes (pN) (p=0.020), lymphovascular invasion (p=0.022), histological grade (p=0.004) and triple negative breast cancer (TNBC) (p=0.004). αB- crystallin expression significantly decreased time to recurrence (p=0.039). CONCLUSION: The results revealed a strong relationship between αB- crystallin and poor prognostic factors such as the number of metastatic lymph nodes (especially pN2), TNBC, and rapid time to recurrence. We believe that αB- crystallin could be a novel oncoprotein biomarker of a poor prognosis in breast cancer.
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Authors | Hae Sung Kim, Younok Lee, Young Ah Lim, Hee Joon Kang, Lee Su Kim |
Journal | Journal of breast cancer
(J Breast Cancer)
Vol. 14
Issue 1
Pg. 14-9
(Mar 2011)
ISSN: 2092-9900 [Electronic] Korea (South) |
PMID | 21847389
(Publication Type: Journal Article)
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